—–Chinyorwa ichi chakakopwa kubvaMedpageToday
Kubvisa mazai maviri asati asvika kumwedzi kunobatanidzwa nehuwandu hwehuwandu hwehutano husingaperi uye kuderedza kushanda kwemuviri makore gare gare, kunyanya muvakadzi vakambovhiyiwa kare, chidzidzo chemuchinjikwa chakawana.
Zvichienzaniswa neboka rinoenderana nezera, vakadzi vari pasi pemakore makumi mana nematanhatu vakaitwa premenopausal bilateral oophorectomy (PBO) nokuda kwemamiriro asina kunaka-ane kana asina hysterectomy-vakaita zvishoma pamuedzo wekufamba kwemaminetsi matanhatu wakaitwa mukiriniki yekunze makumi maviri emakore gare gare uye vainyanya kuitika. kuva nechirwere chisingaperi:
Asthma: kana 1.74 (95% CI 1.03-2.93)
Arthritis: kana 1.64 (95% CI 1.06-2.55)
Kuvharisa kufema kwehope: kana 2.00 (95% CI 1.23-3.26)
Kutsemuka: kana 2.86 (95% CI 1.17-6.98)
"Izvi zvigumisiro zvinoratidzira zvinogona kuitika kwenguva refu zvakashata zvinokonzerwa neoophorectomy kune vakadzi vane bhenen kana vasina zviratidzo zveovarian avo vari pavhareji yengozi yegomarara reovarian," vakapedzisa vatsvakurudzi vakatungamirirwa naMichelle Mielke, MD, PhD, weWake Forest University School of. Mushonga muWinston-Salem, NC, mune chinyorwa muMenopause.Iyi mhedzisiro yakakosha kana uchifunga nezve ovariectomy (PBO) uye hysterectomy.
Stephanie Faubion, MD, MBA, mutungamiri wezvokurapa weMenopause Society, akati zvakawanikwa, izvo zvinoenderana neMayo Clinic's Tubectomy uye Aging Cohort Study-2 (MOA-2), inosimbisa kudiwa kwevanachiremba kuti vachinje maitiro avo.
"Izvi zvinongowedzera kumabhuku aripo ekuti kubvisa maovari pazera diki, kunyanya pasi pemakore makumi mana nematanhatu, kwakabatana nehutano husina kunaka," Faubion akaudza MedPage Nhasi.Panguva ino, ndinofunga kuti tinofanira kungotora matanho. "
Faubion, anove zvakare director weCenter for Women's Health paMayo Clinic muRochester, Minnesota, asi asina kubatanidzwa muongororo yazvino, akati kuroora gare gare (vakadzi vane makore ari pakati pe46 ne49) zvakare "haisi chinhu. pfungwa yakanaka,” maererano neongororo yacho.Muboka iri, maive nekuwedzera kwekusawirirana kweArthritis uye apnea yekurara zvichienzaniswa nezera ravo-rinoenderana nezera, uye PBO yakatungamira kune yakakwira mikana yechirwere chisingaperi chemapapu muboka rose.
Muboka rePBO, inenge 90 muzana yakaitawo hysterectomy, uye 6 muzana yakanga ine hysterectomy isati yasvika;muboka rezera-rinofananidzwa risina kuita PBO, 9 muzana yakanga ine hysterectomy.
Mielke akaudza MedPage Nhasi kuti kubvisa mazai panguva ye hysterectomy (yechipiri kuvhiyiwa kwakawanda kuvakadzi) itsika inowanzoitika kuvakadzi, muchidimbu nokuti inobvisa njodzi yekenza ye ovarian.
“Munhau,” Mielke anotsanangura kudaro, “kwaidavirwa kuti kana chibereko chabviswa, paisazovazve nemano okuberekana, uye naizvozvo paisazova nedikanwo yokubvisa mazai.”Zvisinei, nekufamba kwenguva, kutsvakurudza kwakawanda kwakaratidza kuti kubvisa mazai maviri asati asvika kumwedzi kunogona kuva nemigumisiro yenguva refu kana njodzi dzenguva refu dzezvimwe zvirwere.
Kana mazai akabviswa asati aguma kuenda kumwedzi, Mukaka akati, "zvinokurudzirwa zvakasimba" kuti vakadzi varambe vari paestrogen therapy kusvika pazera remakore makumi mashanu.
Vatsvakurudzi vakacherechedza kuti chidzidzo chemazuva ano chaisanganisira kuongorora kwakazara mu-munhu kwemuviri kwevakadzi vane nhoroondo yakanyorwa yePBO, asi zvimwe zvidzidzo paPBO uye migumisiro yehutano yakatsamira zvakanyanya pakuunganidza kusinganzwisisi kwemigumisiro kubva kune zvinyorwa zvezvokurapa, kukundikana kutora "nzvimbo dzakati. yekushanda kwemuviri kana mamwe matanho ane chekuita nekuchembera.
Tsanangudzo yekudzidza
Mielke nevamwe vaaishanda navo vakashandisa data kubva kuRochester Epidemiology Project's (REP) Medical Record Linkage System uye chidzidzo cheMOA-2, chakaratidza vakadzi muOlmsted County, Minnesota, vakarapwa nePBO nekuda kwemamiriro asina kunaka pakati pa1988 na2007 uye vaive vasipo. njodzi huru yekenza ye ovarian.Vatori veMOA-2 vakafananidzwa neboka rezita revakadzi vasina kugamuchira PBO vakabatanidzwa neboka rekutsvaga revakadzi vasina kugamuchira PBO.
Kubva muna 2018, pakatanga kudzidza kutarisana kumeso, ruzhinji rweavo muPBO nemapoka ereferenzi vaive vachiri vapenyu (91.6% uye 93.1%, zvichiteerana).
Boka rekutsvagisa rakatora 274 vakadzi vaitaura Chirungu kubva kuMOA-2 avo vakawana mu-munhu kuteedzerwa nePBO mushure mepakati pemakore makumi maviri nemaviri, kusanganisira varwere ve161 vakaita chirongwa ichi kare (vasati vava nemakore makumi mana nematanhatu) (59%) uye varwere ve113. avo vakanonoka kuita izvi (makore 46 kusvika 49) (41%).
Vatori vechikamu vaifanira kunge vane makore makumi mashanu neshanu kana kupfuura pakunyoresa uye havana kuverengerwa kana pathology yakaratidza kurwara muPBO yavo kana dai vasina kumboonekwa muREP mumakore apfuura 5.Vakanga vakaenzana nezera kune vatori vechikamu 240 muboka rereferensi vasina PBO.
Pakazara, vakadzi vaive nezera repakati pemakore 67, vaive 97% -99% vachena, uye vangangoita 60% havana kumboputa.
Zvirwere zvisingaperi zvakaongororwa nemabhuku ezvokurapa.Mukuwedzera kune masangano ambotaurwa, vatsvakurudzi havana kuwana hukama pakati pePBO nekenza, chirwere cheshuga, dementia, hypertension, hyperlipidemia, cardiac arrhythmia, itsvo, thyroid, kana chirwere chechiropa, osteoporosis, kana kurwisa kwenguva pfupi ischemic.
Kuongororwa kwepanyama kwaisanganisira zviyero zvesimba uye kufamba.Kuenzaniswa neboka rezera rinoenderana nezera, vakadzi vakawana PBO vaive neakakwira thyroid / pteronavicular mafuta ratio uye vakaita zvisina kunaka pa6-miniti yekufamba bvunzo (-14 metres), nepo vakadzi vakatanga PBO vakaita zvirinani pa6-miniti. kufamba bvunzo (-18 metres).Vakadzi muboka rekupedzisira rePBO vaive nepamusoro pepakati pezana mafuta mashoma, appendicular lean mass, uye spinal bone mineral density zvichienzaniswa neboka rezita.
Mielke nevamwe vaaishanda navo vakacherekedza kuti nekuda kwekuti chidzidzo chacho chaive chepakati-chikamu, causality haigone kuderedzwa, uye zvidzidzo zvenguva refu zvinokurudzirwa.Vakacherechedzawo kuti vakadzi vakapinda muchidzidzo ichi vanogona kunge vaine hutano kudarika ruzhinji rwevanhu uye vakanongedza kuwanda kwevachena seimwe yezvipimo zvechidzidzo.
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Nguva yekutumira: Sep-18-2023