Iyo nyowani yeropa biomarker inogona kubatsira kufanotaura njodzi yeAlzheimer?

Chidzidzo chitsva chinoratidza kuti astrocytes, rudzi rwesero reuropi, yakakosha pakubatanidza amyloid-β nematanho ekutanga etau pathology.Karyna Bartashevich/Stocksy

• Reactive astrocytes, rudzi rwesero reuropi, inogona kubatsira masayendisiti kunzwisisa kuti sei vamwe vanhu vane ruzivo rwakagwinya uye amyloid-β deposits muuropi hwavo vasingagadziri zvimwe zviratidzo zveAlzheimer's, senge tangled tau proteins.
• Chidzidzo chine vanopfuura 1,000 vatori vechikamu vakatarisa biomarkers uye vakawana kuti amyloid-β yaingobatanidzwa nekuwedzera mazinga etau muvanhu vaive nezviratidzo zveastrocyte reactivity.
• Zvakawanikwa zvinoratidza kuti maastrocyte akakosha pakubatanidza amyloid-β nematanho ekutanga etau pathology, izvo zvinogona kushandura matsananguriro atinoita chirwere cheAlzheimer chekutanga.

Iko kuunganidzwa kweamyloid plaques uye tangled tau mapuroteni muuropi kwakagara ichionekwa sechikonzero chikuru cheChirwere cheAlzheimer (AD).

Kuvandudzwa kwezvinodhaka kwave kutarisisa kunanga amyloid uye tau, kuregeredza basa rinogona kuitwa remamwe maitiro ehuropi, senge neuroimmune system.

Ikozvino, tsvagiridzo itsva kubva kuYunivhesiti yePittsburgh Chikoro cheMishonga inoratidza kuti maastrocyte, ari masero europi akaita senyeredzi, anoita basa rakakosha mukuona mafambiro eAlzheimer's.

AstrocytesTrusted Sourceakawanda muuropi tishu.Padivi pemamwe masero eglial, masero ehuropi anogara ekudzivirira muviri, maastrocyte anotsigira neuroni nekuvapa chikafu, oxygen, uye dziviriro kubva kuhutachiona.

Kare basa remaastrocyte mukutaurirana neuronal rakanga rakafuratirwa sezvo maseru eglial asingafambisi magetsi semaneuroni.Asi iyo Yunivhesiti yePittsburg kudzidza inopokana nepfungwa iyi uye inovhenekera basa rakakosha reastrocyte muhutano hwehuropi uye chirwere.

Zvakawanikwa zvakaburitswa munguva pfupi yapfuuraNature MedicineTrusted Source.

Tsvagiridzo yapfuura inoratidza kuti kuvhiringika muhuropi hunoita kuremerwa neamyloid, sekuwedzera kuzvimba kwehuropi, kunogona kuita basa rakakosha mukutanga pathological kutevedzana kwekufa neuronal izvo zvinotungamira nekukurumidza kuderera kwekuziva muAlzheimer's.

Muchidzidzo chitsva ichi, vaongorori vakaita bvunzo dzeropa kune 1,000 vatori vechikamu kubva kuzvidzidzo zvitatu zvakasiyana zvinosanganisira vakura vane hutano hwekuziva vane uye vasina amyloid buildup.

Vakaongorora masampuli eropa kuti vaongorore biomarkers yeastrocyte reactivity, kunyanya glial fibrillary acidic protein (GFAP), pamwe chete nekuvapo kwepathological tau.

Vatsvagiri vakawana kuti avo chete vaive neamyloid mutoro uye maredhi eropa airatidza kusagadzikana kweastrocyte activation kana reactivity vangangove nezviratidzo zveAlzheimer's mune ramangwana.